Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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586
Tocris Bioscience™ JIB 04
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Pan Jumonji inhibitor; active in vivo
| Inhibitors | JIB 04 |
|---|---|
| Product Type | JIB 04 |
| Molecular Weight (g/mol) | 308.76 |
| Purity | >99% |
587
Tocris Bioscience™ L-Ascorbic acid
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L-Ascorbic acid synthesized to Ancillary Material Grade
588
Tocris Bioscience™ sCy5DL-amide
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FDAA for super-resolution microscopy of bacteria
589
Tocris Bioscience™ SCOTfluor 510 Fmoc-Dapa-OH
Fmoc protected fluorescent amino acid for use in solid-phase peptide synthesis to prepare PAINT imaging probes
590
Tocris Bioscience™ Mag-Fura-2 AM
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Magnesium (Mg2+) indicator, membrane permeable
591
Tocris Bioscience™ 2'-MeCCPA
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CAS: 205171-12-6 Molecular Formula: C16H22ClN5O4
| CAS | 205171-12-6 |
|---|---|
| Molecular Formula | C16H22ClN5O4 |
592
Tocris Bioscience™ ICI 204,448 hydrochloride
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κ agonist, acts peripherally
| CAS | 121264-04-8 |
|---|---|
| Solubility | Soluble to 100mM in DMSO |
| Chemical Name or Material | (RS)-[3-[1-[[(3,4-Dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]acetic acid hydrochloride |
| Recommended Storage | Store at Room Temperature |
| Molecular Formula | C23H26Cl2N2O4.HCl |
| Formula Weight | Observed MW: 501.84 |
| Assay Percent Range | >98% |
593
Tocris Bioscience™ GNF 7
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Ras signaling inhibitor; inhibits Ack1 and GCK
| Target | Small G Protein Inhibitors |
|---|---|
| CAS | 839706-07-9 |
| Purity | >98% |
| Chemical Name or Material | Ras GTPase Inhibitors |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C28H24F3N7O2 |
| Formula Weight | 547.53 |
594
Tocris Bioscience™ Roscovitine
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent, selective cyclin-dependent kinase inhibitor
| CAS | 186692-46-6 |
|---|---|
| Molecular Formula | C19H26N6O |
595
Tocris Bioscience™ BS 181 dihydrochloride
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Selective cdk7 inhibitor
| Target | Cyclin-dependent Kinase Inhibitors |
|---|---|
| CAS | 1883548-83-1 |
| Purity | >99% |
| Chemical Name or Material | N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C22H32N6.2HCl |
| Formula Weight | 453.45 |
596
Tocris Bioscience™ CD38 inhibitor
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent CD38 inhibitor; active in vivo
597
Tocris Bioscience™ TM 5275 sodium salt
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Plasminogen activator inhibitor-1 (PAI-1) inhibitor; orally bioavailable
| Target | Additional Synthetic Protease Inhibitors |
|---|---|
| CAS | 1103926-82-4 |
| Purity | >98% |
| Chemical Name or Material | 5-Chloro-2-[[2-[2-[4-(Diphenylmethyl)-1-piperazinyl]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C28H27ClN3NaO5 |
| Formula Weight | 543.97 |
598
Tocris Bioscience™ OG 488 BAPTA-1 AM
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Cell-permeable, fluorescently labeled Ca2+ indicator.
599
Tocris Bioscience™ DMXAA
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mSTING agonist; induces antitumor immunological responses
| Target | STING Agonists |
|---|---|
| CAS | 117570-53-3 |
| Purity | 99% |
| Chemical Name or Material | 5,6-Dimethyl-9-oxo-9 H-xanthene-4-acetic acid |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C17H14O4 |
| Formula Weight | 282.29 |
600
Tocris Bioscience™ WS 383
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent, selective and reversible DCN1-UBC12 interaction inhibitor
| Target | Ubiquitin Ligase (E3) Inhibitors |
|---|---|
| CAS | 2247544-02-9 |
| Purity | 0.98 |
| Chemical Name or Material | 5-[[2-[[(4-Chlorophenyl)methyl]thio]-5-methyl[1,2,4 ]triazolo[1,5-a]pyrimidin-7-yl]thio]-N,N-dimethyl-1 H-tetrazole-1-ethanamine hydrochloride |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C18H20ClN9S2.HCl |